In October 1562, less than three years after her accession to the throne, Elizabeth I contracted the highly-infectious smallpox virus, which led to her becoming critically ill, and subsequently raised questions in relation to the succession of the English monarchy.

The marriage between Lettice and Leicester was formally celebrated on Sunday 21 September 1578, at Leicester's Essex home of Wanstead Hall, almost two years to the date of death of her first husband. Leicester had consulted with his chaplain at Wanstead, Humphrey Tyndall, informing of his intent to marry Lettice in secret, as he felt that public knowledge of their marriage may cause "great damage to his estate", having not previously obtained the consent of the queen (Tallis,

Francis Russell, 2nd Earl of Bedford, had been a popular and active courtier during the reign of Elizabeth I, following in the footsteps of his father, John Russell, 1st Earl of Bedford, a high-ranking councillor during the reigns of the three previous monarchs: Henry VIII, Edward VI and Mary I.

On This Day (10 September) in 1549, Sir Anthony Denny died, likely at his primary residence of Cheshunt, Hertfordshire.

On 08 September 1560, Amy sent away her household for the day, encouraging them to enjoy the first day of the local Abingdon Fair. It was on the servants' return to the hall that evening that they found Amy, at the foot of a ground-floor staircase, dead, with her neck obviously broken.