George Clifford, 3rd Earl of Cumberland, courtier, naval commander and expeditioner, died in October 1605 in Westminster, following a month of ill-health.

With the lease for Durham Place being taken over by Sidney, it became essential for Leicester to identify another local property that would meet his needs, and by June 1569, he had found one: Paget Place. After taking possession of the house, the property was eponymously renamed 'Leicester House', thus becoming the Earl's official residence within the capital, with Jenkins (1972, p.186) describing the house as becoming "the centre of his social and political existence".

Some recommended books which cover various periods of Lettice's life, often in the context of events involving other infamous Tudor figures, including her kinswoman and rival Queen Elizabeth I.

In October 1562, less than three years after her accession to the throne, Elizabeth I contracted the highly-infectious smallpox virus; this led to her becoming critically ill, and subsequently raised questions in regards to the governing of a country with an incapacitated queen, and speculation relating to the future of the English monarchy.

The marriage between Lettice and Leicester was formally celebrated on Sunday 21 September 1578, at Leicester's Essex home of Wanstead Hall, almost two years to the date of death of her first husband. Leicester had consulted with his chaplain at Wanstead, Humphrey Tyndall, informing of his intent to marry Lettice in secret, as he felt that public knowledge of their marriage may cause "great damage to his estate", having not previously obtained the consent of the queen (Tallis,