On 11 November 1565, Ambrose Dudley, 3rd Earl of Warwick, the elder brother of Robert Dudley, 1st Earl of Leicester, was married for the third, and what would be his final time. For the twice-widowed Warwick, now in his mid-thirties, his new bride was the eldest daughter of Francis Russell, 2nd Earl of Bedford, and member of Elizabeth I's household: 15-year-old Lady Anne Russell.

George Clifford, 3rd Earl of Cumberland, courtier, naval commander and expeditioner, died in October 1605 in Westminster, following a month of ill-health.

With the lease for Durham Place being taken over by Sidney, it became essential for Leicester to identify another local property that would meet his needs, and by June 1569, he had found one: Paget Place. After taking possession of the house, the property was eponymously renamed 'Leicester House', thus becoming the Earl's official residence within the capital, with Jenkins (1972, p.186) describing the house as becoming "the centre of his social and political existence".

Some recommended books which cover various periods of Lettice's life, often in the context of events involving other infamous Tudor figures, including her kinswoman and rival Queen Elizabeth I.

In October 1562, less than three years after her accession to the throne, Elizabeth I contracted the highly-infectious smallpox virus; this led to her becoming critically ill, and subsequently raised questions in regards to the governing of a country with an incapacitated queen, and speculation relating to the future of the English monarchy.